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Indotecan(LMP400)

Names

[ CAS No. ]:
915303-09-2

[ Name ]:
Indotecan(LMP400)

[Synonym ]:
3-[(Morpholine)-1-propyl]-5,3-dimethoxy-8,9-meth ylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline
UNII-BTA69L5M8D

Biological Activity

[Description]:

Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Research Areas >> Cancer

[Target]

IC50：300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively[1].


[References]

[1]. Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.


[Related Small Molecules]

Campathecin | 7-Ethyl-10-hydroxycamptothecin | Exatecan (Mesylate) | Daun02 | Idarubicin (hydrochloride) | Beta-Lapachone | Betulinic acid | Teniposide | Amsacrine | TAS 103 | Genz-644282 | Amonafide | Ellipticine (hydrochloride) | Pirarubicin | Banoxantrone dihydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C26H26N2O7

[ Molecular Weight ]:
478.49400

[ Exact Mass ]:
478.17400

[ PSA ]:
88.46000

[ LogP ]:
2.61900

Related Compounds