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HECOGENIN ACETATE

Names

[ CAS No. ]:
915-35-5

[ Name ]:
HECOGENIN ACETATE

[Synonym ]:
MFCD00005088
EINECS 213-021-7
hecogenin acetate

Biological Activity

[Description]:

Hecogenin acetate is a steroidal sapogenin-acetylated with anti-inflammatory and antinociceptive. Hecogenin acetate shows potential antihyperalgesic activity, inhibiting descending pain and acting in opioid receptors[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[References]

[1]. de França Almeida Moreira CDL, et al. Amorphous solid dispersions of hecogenin acetate using different polymers for enhancement of solubility and improvement of anti-hyperalgesic effect in neuropathic pain model in mice. Biomed Pharmacother. 2018 Jan;97:870-879.

[2]. Carvalho YMBG, et al. Inclusion complex between β-cyclodextrin and hecogenin acetate produces superior analgesic effect in animal models for orofacial pain. Biomed Pharmacother. 2017 Sep;93:754-762.

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
557.5ºC at 760mmHg

[ Melting Point ]:
246-248ºC (dec.)(lit.)

[ Molecular Formula ]:
C29H44O5

[ Molecular Weight ]:
472.65700

[ Flash Point ]:
264.7ºC

[ Exact Mass ]:
472.31900

[ PSA ]:
61.83000

[ LogP ]:
5.54360

MSDS

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Safety Information

[ Safety Phrases ]:
S22-S24/25

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds