5,7-Dimethoxyluteolin

Names

[ Name ]:
5,7-Dimethoxyluteolin

[Synonym ]:
Luteolin-5,7-dimethylether
4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-5,7-dimethoxy
2-(3,4-dihydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one

Biological Activity

[Description]:

5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC50 of 3.417 μM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter

Research Areas >> Neurological Disease

[Target]

EC50: 3.417μM (Dopamine transporter) [1]

[References]

[1]. Jiange Zhang, et al. Discovery and synthesis of novel luteolin derivatives as DAT agonists. Bioorg Med Chem. 2010 Nov 15;18(22):7842-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₄O₆

[ Molecular Weight ]:
314.28900

[ Exact Mass ]:
314.07900

[ PSA ]:
89.13000

[ LogP ]:
2.88840

Synthetic Route

Click to get detail synthetic route

Related Compounds

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