Deoxyribonuclease

Names

[ Name ]:
Deoxyribonuclease

[Synonym ]:
Alkaline DNase
Alkaline deoxyribonuclease
DNA depolymerase
DNA endonuclease
DNA nuclease
DNAase
DNase
Deoxyribonuclease A
Deoxyribonuclease I
Deoxyribonucleic phosphatase
Desoxyribonuclease
Dornase
Pancreatic deoxyribonuclease
Pancreatic dornase

Biological Activity

[Description]:

Deoxyribonuclease (DNase) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vivo]

Deoxyribonuclease (0.1 U; i.p.; once daily for 3 days) inhibits liver metastasis, besides results in a greater prolongation of the survival period by combining surgical removal of the primary tumour mass[1]. Animal Model: Female BALB/c x DBA/2 mice with murine tumour L5178Y-ML cells subcutaneous injection[1] Dosage: 0.1 U per mouse Administration: Intravenous injection; 0.1 U; once daily for three days Result: Reduced liver weight from 2.26 to 1.55 g, affected the intensity of liver metastasis, reduced the numbers and sizes of metastatic and affected tumour cell arrest. Animal Model: Female BALB/c x DBA/2 mice with murine tumour and surgical removal of subcutaneous tumours[1] Dosage: 0.1 U per mouse Administration: Intravenous injection; 0.1 U; once daily for 3 days either before or after primary tumour removal Result: Significantly prolongated survival after tumour cell inoculation compared to the untreated group.

Chemical & Physical Properties

[ Density]:
100 g/mL at 20 °C

[ Appearance of Characters ]:
solution (clear, colorless) | white

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in 0.15 M sodium chloride (5.0mg/L) clear.

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
23-24/25-22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RF0750000

Articles

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.

Cell Death Differ. 22 , 1970-84, (2015)

Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...

ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.

Autophagy 11 , 1308-25, (2015)

Recent studies have shown that the phosphorylation and dephosphorylation of ULK1 and ATG13 are related to autophagy activity. Although ATG16L1 is absolutely required for autophagy induction by affecti...

Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.

Autophagy 11(1) , 166-82, (2015)

The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via products translocated thro...