ICI 174,864

Names

[ Name ]:
ICI 174,864

[Synonym ]:
N,N-DIALLYL-TYR-AIB-AIB-PHE-LEU
Antalarmin hydrochloride
N,N-Diallyl-Tyr-aib-Phe-Leu
L-Leucine,N,N-di-2-propenyl-L-tyrosyl-2-methylalanyl-L-phenylalanyl

Biological Activity

[Description]:

ICI 174864 is a highly selective, potent δ-receptor antagonist. ICI 174864 is equipotent with naloxone and can not reverse the effect of the μ-agonist [D-Ala2, MePhe4, Gly-Ol5]enkephalin or the κ-agonist tifluadom[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[References]

[1]. R Cotton, et, al. ICI 174864: a highly selective antagonist for the opioid delta-receptor. Eur J Pharmacol. 1984, 97,3.

Chemical & Physical Properties

[ Density]:
1.16 g/cm3

[ Boiling Point ]:
892.7ºC at 760 mmHg

[ Molecular Formula ]:
C₃₄H₄₆N₄O₆

[ Molecular Weight ]:
606.75

[ Flash Point ]:
493.7ºC

[ Exact Mass ]:
691.39400

[ PSA ]:
177.17000

[ LogP ]:
4.67350

[ Index of Refraction ]:
1.564

Related Compounds

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