ICI 199,441 hydrochloride

Names

[ Name ]:
ICI 199,441 hydrochloride

[Synonym ]:
ici 199,441
ici 199,441 hydrochloride

Biological Activity

[Description]:

ICI 199441 is a potent and selective κ-opioid receptor agonist. ICI 199441 can improve heart resistance to ischemia/reperfusion[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

[In Vivo]

ICI 199441 (Wistar rats, 0.1 mg/kg, IV, once) administered 15 min before ischemia produces a potent antiarrhythmic effect[1].

[References]

[1]. Tsibulnikov SY, et al. Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. Bull Exp Biol Med. 2015;159(6):718-721.

Chemical & Physical Properties

[ Boiling Point ]:
532.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₅Cl₃N₂O

[ Molecular Weight ]:
427.80

[ Flash Point ]:
276ºC

[ Exact Mass ]:
426.10300

[ PSA ]:
23.55000

[ LogP ]:
5.57130

[ Vapour Pressure ]:
1.97E-11mmHg at 25°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.