115199-84-3

115199-84-3 structure

Name: ICI 199,441 hydrochloride
Chemical Name: ICI 199,441 hydrochloride,2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamidehydrochloride
CAS Number: 115199-84-3
Molecular Formula: C₂₁H₂₅Cl₃N₂O
Molecular Weight: 427.80
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2018-05-29 08:00:00
Modify Date: 2025-08-26 21:43:57
ICI 199441 is a potent and selective κ-opioid receptor agonist. ICI 199441 can improve heart resistance to ischemia/reperfusion[1].

Name	ICI 199,441 hydrochloride,2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamidehydrochloride
Synonyms	ici 199,441 ici 199,441 hydrochloride

Description	ICI 199441 is a potent and selective κ-opioid receptor agonist. ICI 199441 can improve heart resistance to ischemia/reperfusion[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
In Vivo	ICI 199441 (Wistar rats, 0.1 mg/kg, IV, once) administered 15 min before ischemia produces a potent antiarrhythmic effect[1].
References	[1]. Tsibulnikov SY, et al. Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. Bull Exp Biol Med. 2015;159(6):718-721.

60725-19-1

115199-84-3

130013-63-7

115199-84-3

116508-51-1

6831-55-6

115199-84-3

Precursor 2
60725-19-1 6831-55-6
DownStream 0