ICI 204,448 hydrochloride

Names

[ Name ]:
ICI 204,448 hydrochloride

[Synonym ]:
MFCD00153814
ICI 204,448 hydrochloride

Biological Activity

[Description]:

ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[References]

[1]. J S Shaw, et, al. ICI 204448: a kappa-opioid agonist with limited access to the CNS. Br J Pharmacol. 1989, 96, 4.

Chemical & Physical Properties

[ Boiling Point ]:
638.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₇Cl₃N₂O₄

[ Molecular Weight ]:
501.83

[ Flash Point ]:
340.2ºC

[ Exact Mass ]:
500.10400

[ PSA ]:
70.08000

[ LogP ]:
5.03470

[ Vapour Pressure ]:
3.39E-17mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.

Proc. Natl. Acad. Sci. U. S. A. 105(49) , 19038-43, (2008)

Previous work from our group showed that intrathecal (i.t.) administration of substances such as glutamate, NMDA, or PGE(2) induced sensitization of the primary nociceptive neuron (PNN hypernociceptio...

Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.

J. Pharmacol. Exp. Ther. 340(3) , 501-9, (2012)

κ opioid receptor agonists that do not readily cross the blood-brain barrier are peripherally restricted and distribute poorly to the central nervous system after systemic administration. Peripherally...

Peripheral kappa-opioid agonist, ICI 204448, evokes hypothermia in cold-exposed rats.

Pharmacology 74(2) , 79-83, (2005)

ICI 204448, a selective kappa-opioid agonist with limited CNS access, can be used to discriminate central and peripheral opioid actions on physiological systems such as pain and thermoregulation. Ther...