Menthol

Names

[ CAS No. ]:
89-78-1

[ Name ]:
Menthol

[Synonym ]:
EINECS 216-074-4
Cyclohexanol, 2-isopropyl-5-methyl-
Menthol, dl-
D-2-amino-5-phosphonovaleric acid
Menthol (VAN)
APV
MENTHOLS
AP-5
MENTHOL CRYSTALS
DL-MENTHOL FOR SYNTHESIS
DL-APV
MENTHOL 99
(+/-)-MENTHOL
DL-MENTHAN-3-OL
RACEMIC MENTHO
DL-MENTHOL, CERTIFIED REFERENCE MATERIAL
hexahydrothymol
Menthol
rac-Menthol
2-Isopropyl-5-methylcyclohexanol
5-PHOSPHONO-DL-NORVALINE
dl-Peppermint
I-menthol
CYCLOHEXANOL,5-METHYL-2-(1-METHYLETHYL)-, (1R,2S,5R)-REL-
UNII:39PJ29YY8Z
2-isopropyl-5-methyl-cyclohexanol
p-Menthan-3-ol
(1R,2S,5R)-rel-2-Isopropyl-5-methylcyclohexanol
DL-2-amino-5-phosphonovaleric acid
Fancol menthol
Racemic menthol
4-isopropyl-1-methylcyclohexan-3-ol
DL-AP5
MENTHOL RACEMIC
5-Phosphononorvaline
2-amino-5-phosphopentanoicacid
(-a)-MENTHOL RACEMIC
2-amino-5-phosphonovaleric acid
Norvaline, 5-phosphono-
MENTHOL RAC
Cyclohexanol, 5-methyl-2-(1-methylethyl)-
MENTHOMENTHOL
MFCD00001484
2-amino-5-phosphovaleric acid
3 para menthanol
Menthacamphor

Biological Activity

[Description]:

DL-Menthol is a relative configuration of (-)-Menthol. DL-Menthol induces surgical anesthesia for fish that relates to the activation of GABAA receptor[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Menthol Induces Surgical Anesthesia and Rapid Movement in Fishes. The Open Neuroscience. 2014 Feb; 8(1):1-8.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
215.4±8.0 °C at 760 mmHg

[ Melting Point ]:
34-36 °C(lit.)

[ Molecular Formula ]:
C₁₀H₂₀O

[ Molecular Weight ]:
156.265

[ Flash Point ]:
93.3±0.0 °C

[ Exact Mass ]:
156.151413

[ PSA ]:
20.23000

[ LogP ]:
3.20

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.457

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OT0350000

CHEMICAL NAME :: Menthol

CAS REGISTRY NUMBER :: 89-78-1

BEILSTEIN REFERENCE NO. :: 1902288

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C10-H20-O

MOLECULAR WEIGHT :: 156.30

WISWESSER LINE NOTATION :: L6TJ AY1&1 BQ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3180 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - hallucinations, distorted perceptions Behavioral - muscle weakness

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 10,481,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,244,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 63,43,1939

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 63,43,1939 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22400 mg/kg/28D-I

TOXIC EFFECTS :: Behavioral - fluid intake Liver - changes in liver weight Blood - changes in other cell count (unspecified)

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 19,207,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 44440 No. of Facilities: 3689 (estimated) No. of Industries: 36 No. of Occupations: 35 No. of Employees: 25754 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 44440 No. of Facilities: 2880 (estimated) No. of Industries: 28 No. of Occupations: 33 No. of Employees: 44233 (estimated) No. of Female Employees: 31143 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S36/37/39-S24/25-S36-S26

[ RIDADR ]:
UN 1888 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
OT0350000

[ HS Code ]:
2906110000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2906110000

[ Summary ]:
2906110000 2-isopropyl-5-methylcyclohexanol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:13.0%

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