PRECLAMOL HYDROCHLORIDE

Names

[ Name ]:
PRECLAMOL HYDROCHLORIDE

Biological Activity

[Description]:

Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. Preclamol hydrochloride has the potential for the research of schizophrenia[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Seth-Olov Thorberg, et al. Large scale synthesis and absolute configuration of (-)-3-ppp, a selective dopamine autoreceptor agonist. Tetrahedron. 1985, 41(1): 129-139.

[2]. Tamminga CA, et al. Pharmacologic properties of (-)-3PPP (preclamol) in man. J Neural Transm Gen Sect. 1992;88(3):165-75.

Chemical & Physical Properties

[ Boiling Point ]:
342.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₂ClNO

[ Molecular Weight ]:
255.78

[ Flash Point ]:
158ºC

[ Exact Mass ]:
255.13900

[ PSA ]:
23.47000

[ LogP ]:
3.72150

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP.

Psychopharmacology 81 , 89-99, (1983)

The two enantiomers of the putative centrally acting dopamine (DA) autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine, 3-PPP (Hjorth et al. 1981), were pharmacologically evaluated. An exten...

Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers.

Psychopharmacology 81 , 199-207, (1983)

The pharmacological profile of the enantiomers of the proposed selective dopamine (DA) autoreceptor agonist 3-PPP [3-(3-hydroxyphenyl)-N-n-propylpiperidine] has been studied. In vitro both enantiomers...

(+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)-piperidine binding to sigma receptors in mouse brain in vivo.

Eur. J. Pharmacol. 161 , 263-266, (1989)

Binding of i.v. administered (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ([3H]3-PPP) in the brain of intact mice is antagonized dose responsively by sigma receptor ligands. The correlation of p...

Related Compounds

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