Butyrolactone I

Names

[ Name ]:
Butyrolactone I

Biological Activity

[Description]:

Butyrolactone I is an ATP-competitive inhibitor of CDK1 as a secondary metabolite from A. terreus[1]. Butyrolactone I has antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK1

[References]

[1]. Nishio K, et al. Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines. Anticancer Res. 1996 Nov-Dec;16(6B):3387-95. P

[2]. Suzuki M, et al. Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Cancer Lett. 1999 Apr 26;138(1-2):121-30.

Chemical & Physical Properties

[ Density]:
1.342g/cm3

[ Boiling Point ]:
661.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₄O₇

[ Molecular Weight ]:
424.44300

[ Flash Point ]:
228ºC

[ Exact Mass ]:
424.15200

[ PSA ]:
113.29000

[ LogP ]:
3.58690

[ Index of Refraction ]:
1.633

Related Compounds

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