6-Aminouracil

Names

[ CAS No. ]:
873-83-6

[ Name ]:
6-Aminouracil

[Synonym ]:
4-Amino-2,6-dihydroxypyrimidine
6-Amino-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-amino-
4-AMINOURACI
6-amino-1H-pyrimidine-2,4-dione
MFCD00006071
6-aminopyrimidine-2,4-diol
Pyrimidine, 2,4-dihydroxy-6-amino
4-ADHP
EINECS 212-854-3
2,4-Dihydroxy-6-aminopyrimidine
AURORA KA-377
2,4-Dioxo-6-imino-1,3-diaza-hexahydrobenzol
6-aminopyrimidine-2,4(1H,3H)-dione
Barbitursaeure-4-imin
6-amino-1,2,3,4-tetrahydro-2,4-dioxopyrimidine
Imino-4-uracil
6-amino-5H-pyrimidine-2,4-dione
Aminouracil
2,6-Dioxo-4-imino-hexahydropyrimidin
6-Aminouracil
6-amino-1H,3H-pyrimidine-2,4-dione
4-AMINOURACIL

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
580.4±53.0 °C at 760 mmHg

[ Melting Point ]:
≥360 °C(lit.)

[ Molecular Formula ]:
C₄H₅N₃O₂

[ Molecular Weight ]:
127.101

[ Flash Point ]:
304.8±30.9 °C

[ Exact Mass ]:
127.038177

[ PSA ]:
91.74000

[ LogP ]:
-2.33

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.746

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ8750000

CHEMICAL NAME :: Uracil, 6-amino-

CAS REGISTRY NUMBER :: 873-83-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H5-N3-O2

MOLECULAR WEIGHT :: 127.12

WISWESSER LINE NOTATION :: T6MVMVJ FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,696,1955

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YQ8750000

[ HS Code ]:
29335995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

Mini Rev. Med. Chem. 5(12) , 1113-23, (2005)

Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolys...

Synthesis of 6-aminouracils and pyrrolo[2,3-d]pyrimidine-2,4-diones and their inhibitory effect on thymidine phosphorylase.

Nucleic Acids Symp. Ser. (37) , 59-60, (1997)

Inhibitors of thymidine phosphorylase (dThdPase) are expected to suppress the growth and metastasis of tumor cells by inhibition of angiogenesis and were designed by utilizing the three dimensional st...

Synthesis, chemical and pharmacological properties of some 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido [4,5-d]pyrimidines.

Acta Pol. Pharm. 53(1) , 39-46, (1996)

Synthesis of 6-substituted 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidines [III-VI] obtained by cyclocondensation of 1-phenyl-6-aminouracil with formaline and the primary amines is descr...