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TCS 3035

Names

[ CAS No. ]:
871085-49-3

[ Name ]:
TCS 3035

Biological Activity

[Description]:

GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

GPR35[1]


[References]

[1]. Jenkins L, et al. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2. Br J Pharmacol. 2011 Feb;162(3):733-48.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H9NO5S

[ Molecular Weight ]:
279.27

[ Exact Mass ]:
279.02000

[ PSA ]:
118.00000

[ LogP ]:
1.80270

Related Compounds