Euphohelioscopin A

Names

[ Name ]:
Euphohelioscopin A

[Synonym ]:
(1aR,2Z,4aR,6R,7S,7aS,8Z,10R,11aS)-4a-Acetoxy-7-hydroxy-1,1,3,6,9-pentamethyl-4-oxo-1a,4,4a,5,6,7,7a,10,11,11a-decahydro-1H-cyclopenta[a]cyclopropa[f][11]annulen-10-yl (2E,4Z)-2,4-octadienoate
2,4-Octadienoic acid, (1aR,2Z,4aR,6R,7S,7aS,8Z,10R,11aS)-4a-(acetyloxy)-1a,4,4a,5,6,7,7a,10,11,11a-decahydro-7-hydroxy-1,1,3,6,9-pentamethyl-4-oxo-1H-cyclopenta[a]cyclopropa[f]cycloundecen-10-yl ester, (2E,4Z)-

Biological Activity

[Description]:

Euphohelioscopin A is a diterpenoid can be isolated from the Euphorbia helioscopia L. plant. Euphohelioscopin A weakly inhibits P-glycoprotein-mediated efflux of mitoxantrone[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[References]

[1]. Barile E, et al. Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators. Org Biomol Chem. 2008 May 21;6(10):1756-62.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
589.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₂O₆

[ Molecular Weight ]:
498.65

[ Flash Point ]:
182.6±23.6 °C

[ Exact Mass ]:
498.298126

[ PSA ]:
89.90000

[ LogP ]:
6.09

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.545

Related Compounds

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