Neurokinin A trifluoroacetate salt

Names

[ CAS No. ]:
86933-74-6

[ Name ]:
Neurokinin A trifluoroacetate salt

[Synonym ]:
Neurokinin A [NKA]
MFCD00167560
A-neurokinin
HKTDSFVGLM-NH2

Biological Activity

[Description]:

Neurokinin A acts via neurokinin 2 (NK-2) receptor.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Peptides

[Target]

NK-2 receptor[1]

[In Vitro]

Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].

[References]

[1]. Gerard NP, et al. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.305 g/cm3

[ Boiling Point ]:
1610.7ºC at 760 mmHg

[ Molecular Formula ]:
C₅₀H₈₀N₁₄O₁₄S

[ Molecular Weight ]:
1133.32000

[ Flash Point ]:
927.9ºC

[ Exact Mass ]:
1132.57000

[ PSA ]:
488.77000

[ LogP ]:
1.05310

[ Index of Refraction ]:
1.58

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Neurogenic airway inflammation induced by repeated intra-esophageal instillation of HCl in guinea pigs.

Inflammation 36(2) , 493-500, (2013)

This study was conducted to investigate if repeated intra-esophageal acid administrations may induce neurogenic inflammation in the airways and nodose ganglion in a guinea pig model. Guinea pigs were ...

Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.

Neuropeptides 47(1) , 9-18, (2013)

The present study was planned to evaluate role of tachykinins (TKs) and neurokinin (NK) receptors in the regulation of gastric motility in sheep. We examined the effects of intravenous (i.v.) injectio...

Neuromodulation mediated by the tachykinin NK3-receptor agonist [MePhe7]-neurokinin B in the isolated perfused lung of nonsensitized nonchallenged and ovalbumin-sensitized and -challenged guinea pig.

Exp. Lung Res. 38(5) , 233-49, (2012)

The neuromodulatory action of the tachykinin NK(3)-receptor agonist [MePhe(7)]-neurokinin B ([MePhe(7)]-NKB) was evaluated on vagal stimulation-induced bronchoconstriction in nonsensitized nonchalleng...