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ABT-384

Names

[ CAS No. ]:
868623-40-9

[ Name ]:
ABT-384

Biological Activity

[Description]:

ABT-384 is a selective 11-β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor. ABT-384 blocks regeneration of active cortisol. ABT-384 exhibits high affinity against rodent, monkey, and human HSD-1 whit a Ki of 0.1-2.7 nM[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[In Vivo]

ABT-384 can be used for the research of the Cushing’s syndrome, obesity, insulin resistance, hypertension, dyslipidemia, osteoporosis, glaucoma, major depressive disorder, and Alzheimer’s disease (AD) [2] .

[References]

[1]. [1] Katz DA, et al. Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384. Transl Psychiatry. 2013;3(8):e295. Published 2013 Aug 27.

[2]. [2] Liu W, et al. Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults. Clin Pharmacol Drug Dev. 2013;2(2):133-151.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H34F3N5O2

[ Molecular Weight ]:
493.56

Related Compounds