Litoxetine

Names

[ Name ]:
Litoxetine

[Synonym ]:
Litoxetinum [INN-Latin]
Litoxetina
Litoxetine
Litoxetinum
Litoxetina [INN-Spanish]

Biological Activity

[Description]:

Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT3 receptor antagonist with a Ki of 85 nM for cerebral 5-HT3 receptors. Litoxetine is an antidepressant and has antiemetic properties[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. I Angel, et al. Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Eur J Pharmacol. 1993 Mar 2;232(2-3):139-45.

Chemical & Physical Properties

[ Density]:
1.1g/cm3

[ Boiling Point ]:
387.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₉NO

[ Molecular Weight ]:
241.32800

[ Flash Point ]:
159.2ºC

[ Exact Mass ]:
241.14700

[ PSA ]:
21.26000

[ LogP ]:
3.43720

[ Index of Refraction ]:
1.607

Related Compounds

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