Di-tert-butyl iminodiacetate

Names

[ Name ]:
Di-tert-butyl iminodiacetate

[Synonym ]:
MFCD01863672
nitrilodiacetic acid di-tert-butyl ester
(tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester
Bis(2-methyl-2-propanyl) 2,2'-iminodiacetate
aminodiacetic acid di-tert-butyl ester
Di-tert-butyl iminodiacetate
di-tert-butyl 2,2'-iminodiacetate
HN(CH2CO2-tBu)2
iminodiacetic acid di-tert-butyl ester
Glycine, N-[2-(1,1-dimethylethoxy)-2-oxoethyl]-, 1,1-dimethylethyl ester
Di-tert-butyl iminodiacetate

Biological Activity

[Description]:

NH-bis(C1-Boc)is a uncleavable linker used for antibody-drug conjugates (ADC).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Noncleavable

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
298.0±25.0 °C at 760 mmHg

[ Melting Point ]:
38-42ºC(lit.)

[ Molecular Formula ]:
C₁₂H₂₃NO₄

[ Molecular Weight ]:
245.315

[ Flash Point ]:
134.0±23.2 °C

[ Exact Mass ]:
245.162704

[ PSA ]:
64.63000

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.446

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Multivalent carbocyanine molecular probes: synthesis and applications.

Bioconjug. Chem. 16(1) , 51-61, (2005)

Synergistic multivalent interactions can amplify desired chemical or biological molecular recognitions. We report a new class of multicarboxylate-containing carbocyanine dye constructs for use as opti...

A facile route to difunctionalized monosubstituted octasilsesquioxanes. Liu H, et al.

Chemistry 17(18) , 5019-5023, (2011)

Fluorous mixture synthesis of asymmetric dendrimers. Jiang ZX and Yu YB.

J. Org. Chem. 75(6) , 2044-2049, (2010)

Related Compounds

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Di-​tert-​butyl iminodiacetate