tert-Butanol
Names
[ CAS No. ]:
75-65-0
[ Name ]:
tert-Butanol
[Synonym ]:
2-Propanol, 2-methyl-
tBuOH
tert-butylalcohol
2-Propanol,2-methyl
tert-Butanol
Trimethylcarbinol
1,1-dimethylethanol
2-Methyl-2-propanol
t-Butyl hydroxide
EINECS 200-751-6
2-Methylpropan-2-ol
tert-Butyl Alcohol
butanol
tert-butyl alcohol, anhydrous
2-Methyl-propan-2-ol
2-Methylpropan-2-olato
T-BUTANOL
MFCD00004464
tert Butyl Alcohol
Methanol, trimethyl-
t-butyl alcohol
tertiry butyl alcohol
-Butyl alcohol
propan-2-ol, 2-methyl-
tertiary alcohol
Trimethyl methanol
tertiary-Butanol
Chemical & Physical Properties
[ Density]:
0.8±0.1 g/cm3
[ Boiling Point ]:
84.6±8.0 °C at 760 mmHg
[ Melting Point ]:
23-26 °C(lit.)
[ Molecular Formula ]:
C4H10O
[ Molecular Weight ]:
74.122
[ Flash Point ]:
11.7±0.0 °C
[ Exact Mass ]:
74.073166
[ PSA ]:
20.23000
[ LogP ]:
0.51
[ Vapour density ]:
2.55 (vs air)
[ Vapour Pressure ]:
46.0±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.395
[ Stability ]:
Stable. Very flammable. Incompatible with strong oxidizing agents, copper, copper alloys, alkali metals, aluminium.
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EO1925000
- CHEMICAL NAME :
- tert-Butyl alcohol
- CAS REGISTRY NUMBER :
- 75-65-0
- BEILSTEIN REFERENCE NO. :
- 0906698
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 48
- MOLECULAR FORMULA :
- C4-H10-O
- MOLECULAR WEIGHT :
- 74.14
- WISWESSER LINE NOTATION :
- QX1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3500 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 399 mg/kg
- TOXIC EFFECTS :
- Liver - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1538 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3559 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - corneal damage Cardiac - pulse rate Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 12 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 gm/kg/94D-C
- TOXIC EFFECTS :
- Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 703 gm/kg/94D-C
- TOXIC EFFECTS :
- Behavioral - fluid intake Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 146 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1540 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 2000 ppm/7H
- SEX/DURATION :
- female 1-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 3500 ppm/7H
- SEX/DURATION :
- female 1-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 103 gm/kg
- SEX/DURATION :
- female 6-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 135 gm/kg
- SEX/DURATION :
- female 6-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - live birth index (measured after birth)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20240 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA
- TEST SYSTEM :
- Insect - not otherwise specified
- REFERENCE :
- ENECEV Environment and Ecology. (Environment and Ecology, C/o Dr. S.K. Konar, Dept. of Zoology, Kalyani University, Kalyani 741253, West Bengal, India) V.1- 1983- Volume(issue)/page/year: 5,321,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 303 mg/m3 (100 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 8,627,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 100 ppm (300 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,32,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 100 ppm (300 mg/m3);STEL 150 ppm (450 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-BELGIUM:TWA 100 ppm (303 mg/m3);STEL 150 ppm (455 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (150 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-GERMANY:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-SWEDEN:TWA 50 ppm (150 mg/m3);STEL 75 ppm (250 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 100 ppm (300 mg/m3);STEL 200 ppm (600 mg/m3) JAN 1993 OEL-TURKEY:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (300 mg/m3);STEL 150 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO t-BUTYL ALCOHOL-air:10H TWA 100 ppm;STEL 150 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14400 No. of Facilities: 820 (estimated) No. of Industries: 11 No. of Occupations: 25 No. of Employees: 3121 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14400 No. of Facilities: 10682 (estimated) No. of Industries: 128 No. of Occupations: 84 No. of Employees: 171420 (estimated) No. of Female Employees: 26045 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H319-H332-H335-H336
[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338-P370 + P378-P403 + P235
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable
[ Risk Phrases ]:
R11;R20
[ Safety Phrases ]:
S9-S16-S45-S36/37-S7
[ RIDADR ]:
UN 1120 3/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
EO1925000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
2905143000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2905143000
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