Thrombin inhibitor 1

Names

[ CAS No. ]:
855998-46-8

[ Name ]:
Thrombin inhibitor 1

Biological Activity

[Description]:

Thrombin inhibitor 1 is a potent thrombin inhibitor (Ki=0.66 nM, 2xaPTT=0.43 μM).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
Research Areas >> Cardiovascular Disease

[Target]

Ki: 0.66 nM (thrombin)[1]


[In Vitro]

Thrombin inhibitor 1 (Compound 4) is binds in the active site of thrombin with Ki of 0.66 nM, 2xaPTT=0.43 uM). Thrombin inhibitor 1 (Compound 4) is evaluated for its thrombin inhibitory potency and its functional ability to double the activated partial thromboplastin time (2xaPTT) in human plasma with a 2xaPTT of 0.43 μM[1].

[References]

[1]. Nantermet PG, et al. P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2771-5.


[Related Small Molecules]

AEBSF HCl | Bivalirudin trifluoroacetate salt | Thrombin | Metolazone | Inogatran | Napsagatran hydrate | NQ 301 | RWJ-445167 | Desethyl KBT-3022 | OM-189 | TRAP-14 trifluoroacetate salt

Chemical & Physical Properties

[ Molecular Formula ]:
C22H20Cl2F2N4O3

[ Molecular Weight ]:
497.32

Related Compounds