Thrombin inhibitor 7

Names

[ CAS No. ]:
2866508-00-9

[ Name ]:
Thrombin inhibitor 7

Biological Activity

[Description]:

Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Thrombin inhibitor 7 (compound 33b) (0-300 µM; 24 h) shows low cytotoxicity in HepG2, A549 cells[1]. Cell Cytotoxicity Assay[1] Cell Line: HepG2, A549 cells Concentration: 0-300 µM Incubation Time: 24 h Result: Showed low cytotoxicity in HepG2, A549 cells.

[References]

[1]. Imberg L, et al. Amide-functionalized 1,2,4-Triazol-5-amines as Covalent Inhibitors of Blood Coagulation Factor XIIa and Thrombin. ACS Pharmacol Transl Sci. 2022 Nov 30;5(12):1318-1347.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H23N7O2

[ Molecular Weight ]:
465.51

Related Compounds