LRRK2 inhibitor 1

Names

[ CAS No. ]:
1802525-61-6

[ Name ]:
LRRK2 inhibitor 1

Biological Activity

[Description]:

LRRK2 inhibitor 1 is a potent, selective and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.

[Related Catalog]:

Signaling Pathways >> Autophagy >> LRRK2
Research Areas >> Neurological Disease

[Target]

pIC50: 6.8 nM (LRRK2)[1]


[References]

[1]. Ding X, et al. Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors. Bioorg Med Chem Lett. 2018 May 15;28(9):1615-1620.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23N5O4

[ Molecular Weight ]:
397.43

[ Storage condition ]:
2-8℃

Related Compounds