mTOR Inhibitor 1

Names

[ CAS No. ]:
2219323-96-1

[ Name ]:
mTOR Inhibitor 1

Biological Activity

[Description]:

mTOR Inhibitor 1 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR Inhibitor 1 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer

[Target]

mTOR:7 nM (IC50)


[References]

[1]. Guo Q, et al. Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer. J Med Chem. 2018 Feb 8;61(3):881-904.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H21N7O

[ Molecular Weight ]:
411.46

Related Compounds