sEH inhibitor-1

Names

[ CAS No. ]:
1208549-68-1

[ Name ]:
sEH inhibitor-1

[Synonym ]:
Urea, N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-
1-[1-(Cyclopropylcarbonyl)-4-piperidinyl]-3-[4-(trifluoromethoxy)phenyl]urea

Biological Activity

[Description]:

sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

sEH[1]

[References]

[1]. Liu JY, et al. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci. 2013;48(4-5):619-627.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
470.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₀F₃N₃O₃

[ Molecular Weight ]:
371.354

[ Flash Point ]:
238.5±28.7 °C

[ Exact Mass ]:
371.145691

[ PSA ]:
70.67000

[ LogP ]:
2.15

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.556

Related Compounds

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