<Suppliers Price>

EX-527 (S-enantiomer)

Names

[ CAS No. ]:
848193-68-0

[ Name ]:
EX-527 (S-enantiomer)

[Synonym ]:
(S)-selisistat
OCZ
S1541_Selleck
(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
cc-651
1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1S)-
EX527
EX-527 S-enantiomer
EX-527 (S-enantiomer)

Biological Activity

[Description]:

Selisistat S-enantiomer (EX-527 S-enantiomer) is the S-enantiomer of Selisistat, with an IC50 of 123 nM for SIRT1. Selisistat S-enantiomer is much more potent than Selisistat R-enantiomer.

[Related Catalog]:

Research Areas >> Cancer

[Target]

SIRT1:123 nM (IC50)


[References]

[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.


[Related Small Molecules]

Selisistat (EX 527) | Nicotinamide | SRT1720 HCl | Sirtinol | 3-TYP | SRT 2104 | Fisetin | OSS_128167 | Thiomyristoyl | Cambinol | Tenovin-1 | CAY10602 | AK-7 | Inauhzin | Tenovin 6 Hydrochloride

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
531.7±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H13ClN2O

[ Molecular Weight ]:
248.708

[ Flash Point ]:
275.4±26.8 °C

[ Exact Mass ]:
248.071640

[ PSA ]:
59.87000

[ LogP ]:
2.22

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.688

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.