Necrostatin 2 (S enantiomer)
Names
[ CAS No. ]:
852391-20-9
[ Name ]:
Necrostatin 2 (S enantiomer)
[Synonym ]:
Necrostatin 2 (S enantiomer)
Necrostatin 2 S enantiomer
Biological Activity
[Description]:
Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.IC50 Value: 50 nM (EC50) [1]Target: TNF-alphaNecrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C13H12ClN3O2
[ Molecular Weight ]:
277.70600
[ Exact Mass ]:
277.06200
[ PSA ]:
65.20000
[ LogP ]:
2.18070
[ Storage condition ]:
2-8℃