Arbaclofen placarbil

Names

[ Name ]:
Arbaclofen placarbil

[Synonym ]:
XP19986
(3R)-3-(4-Chlorophenyl)-4-({[(1S)-1-(isobutyryloxy)-2-methylpropoxy]carbonyl}amino)butanoic acid
UNII-W89H91R7VX
Arbaclofen placarbil
Benzenepropanoic acid, 4-chloro-β-[[[[(1S)-2-methyl-1-(2-methyl-1-oxopropoxy)propoxy]carbonyl]amino]methyl]-, (βR)-

Biological Activity

[Description]:

Arbaclofen placarbil is a novel transported prodrug of the active R-isomer of baclofen. Baclofen is a racemic GABAB receptor agonist

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Lal R, Sukbuntherng J, Tai EH, et al. Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen. J Pharmacol Exp Ther. 2009;330(3):911-921.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
545.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₆ClNO₆

[ Molecular Weight ]:
399.866

[ Flash Point ]:
283.5±30.1 °C

[ Exact Mass ]:
399.144867

[ PSA ]:
105.42000

[ LogP ]:
4.39

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.523

Synthetic Route

Click to get detail synthetic route

Related Compounds

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