847353-30-4

847353-30-4 structure

Name: Arbaclofen placarbil
Chemical Name: (3R)-3-(4-chlorophenyl)-4-[[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino]butanoic acid
CAS Number: 847353-30-4
Molecular Formula: C₁₉H₂₆ClNO₆
Molecular Weight: 399.866
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2017-08-05 17:17:48
Modify Date: 2025-08-22 14:33:48
Arbaclofen placarbil is a novel transported prodrug of the active R-isomer of baclofen. Baclofen is a racemic GABAB receptor agonist

Name	(3R)-3-(4-chlorophenyl)-4-[[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino]butanoic acid
Synonyms	XP19986 (3R)-3-(4-Chlorophenyl)-4-({[(1S)-1-(isobutyryloxy)-2-methylpropoxy]carbonyl}amino)butanoic acid UNII-W89H91R7VX Arbaclofen placarbil Benzenepropanoic acid, 4-chloro-β-[[[[(1S)-2-methyl-1-(2-methyl-1-oxopropoxy)propoxy]carbonyl]amino]methyl]-, (βR)-

Description	Arbaclofen placarbil is a novel transported prodrug of the active R-isomer of baclofen. Baclofen is a racemic GABAB receptor agonist
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Lal R, Sukbuntherng J, Tai EH, et al. Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen. J Pharmacol Exp Ther. 2009;330(3):911-921.

1422187-63-0

847353-27-9

847353-30-4

Literature: XENOPORT, INC.; RAILLARD, Stephen P; MANTHATI, Suresh K; JOSHI, Sudhir Patent: WO2013/23155 A1, 2013 ;