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TCS 2312

Names

[ CAS No. ]:
838823-31-7

[ Name ]:
TCS 2312

[Synonym ]:
TCS 2312
Anpirtoline hydrochloride

Biological Activity

[Description]:

CHK1-IN-7 (Compound 10c) is a potent human CHK1 inhibitor. CHK1-IN-7 shows no single agent effect, potentiates the antiproliferative effect of Gemcitabine HY-17026 in both prostate and breast cancer cell lines. CHK1-IN-7 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Checkpoint Kinase (Chk)

[References]

[1]. Teng M, et al. Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J Med Chem. 2007 Nov 1;50(22):5253-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H24N4O2

[ Molecular Weight ]:
412.48

[ Exact Mass ]:
412.19000

[ PSA ]:
93.20000

[ LogP ]:
5.61440

Related Compounds