SCH 32615

Names

[ Name ]:
SCH 32615

[Synonym ]:
(N-(1-Carboxy-2-phenyl)ethyl)phenylalanyl-B-alanine

Biological Activity

[Description]:

SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

enkephalinase[1]

[In Vitro]

SCH 32615 blocks the degradation of Met5-enkephalin by isolated enkephalinase, with the Ki of 19.5 nM[3].

[In Vivo]

SCH 32615 (150 mg/kg; s.c.) enhances surgery activated endogenous analgesia in mice[1].

[References]

[1]. Jayaram A, et, al. An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology. 1995 May;82(5):1283-7.

[2]. Jayaram A, et, al. SCH 32615, an enkephalinase inhibitor, enhances pregnancy-induced analgesia in mice. Anesth Analg. 1995 May;80(5):944-8.

[3]. Chipkin RE, et, al. Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38.

Chemical & Physical Properties

[ Density]:
1.267g/cm3

[ Boiling Point ]:
683ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₄N₂O₅

[ Molecular Weight ]:
384.42600

[ Flash Point ]:
366.9ºC

[ Exact Mass ]:
384.16900

[ PSA ]:
119.22000

[ LogP ]:
2.70530

[ Index of Refraction ]:
1.594

Related Compounds

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