Fengabine

Names

[ CAS No. ]:
80018-06-0

[ Name ]:
Fengabine

[Synonym ]:
SL 79-229
FENGABINE
Fengabinum
Fengabina

Biological Activity

[Description]:

Fengabine is a GABAergic antidepressant drug. Fengabine can be used for the research of depression[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vivo]

Fengabine (50 mg/kg; i.p.; 2 days) prevents completely the learned helplessness induced by the unavoidable shock[1]. Fengabine (150 mg/kg; i.p) decreases the percentage of time spent. Fengabine (25~50 mg/kg; i.p.) reverses the deficit in learning the step-down avoidance task[1]. Animal Model: Rats Dosage: 50 mg/kg Administration: I.p. Result: Prevented completely the learned helplessness induced by the unavoidable shock.

[References]

[1]. Ascalone V, et al. Determination of the GABAergic antidepressant drug fengabine and some of its metabolites in plasma by capillary gas chromatography with electron-capture detection. J Chromatogr. 1989;490(1):81-90.

[2]. Lloyd KG, et al. Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. J Pharmacol Exp Ther. 1987;241(1):245-250.

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
442.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇Cl₂NO

[ Molecular Weight ]:
322.22900

[ Flash Point ]:
221.2ºC

[ Exact Mass ]:
321.06900

[ PSA ]:
32.59000

[ LogP ]:
5.33650

[ Index of Refraction ]:
1.598

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK1253333

CHEMICAL NAME :: Phenol, 2-((butylimino)(2-chlorophenyl)methyl)-4-chloro-

CAS REGISTRY NUMBER :: 80018-06-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H17-Cl2-N-O

MOLECULAR WEIGHT :: 322.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2068960

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.