Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Fengabine
Price: Check
Purity: 98.54%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Fengabine
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

80018-06-0

80018-06-0 structure

80018-06-0 structure

Name: Fengabine
Chemical Name: (6Z)-6-[butylamino-(2-chlorophenyl)methylidene]-4-chlorocyclohexa-2,4-dien-1-one
CAS Number: 80018-06-0
Molecular Formula: C₁₇H₁₇Cl₂NO
Molecular Weight: 322.22900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-09-11 14:17:27
Modify Date: 2025-10-19 11:44:37
Fengabine is a GABAergic antidepressant drug. Fengabine can be used for the research of depression[1].

Name	(6Z)-6-[butylamino-(2-chlorophenyl)methylidene]-4-chlorocyclohexa-2,4-dien-1-one
Synonyms	SL 79-229 FENGABINE Fengabinum Fengabina

Description	Fengabine is a GABAergic antidepressant drug. Fengabine can be used for the research of depression[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo	Fengabine (50 mg/kg; i.p.; 2 days) prevents completely the learned helplessness induced by the unavoidable shock[1]. Fengabine (150 mg/kg; i.p) decreases the percentage of time spent. Fengabine (25~50 mg/kg; i.p.) reverses the deficit in learning the step-down avoidance task[1]. Animal Model: Rats Dosage: 50 mg/kg Administration: I.p. Result: Prevented completely the learned helplessness induced by the unavoidable shock.
References	[1]. Ascalone V, et al. Determination of the GABAergic antidepressant drug fengabine and some of its metabolites in plasma by capillary gas chromatography with electron-capture detection. J Chromatogr. 1989;490(1):81-90. [2]. Lloyd KG, et al. Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. J Pharmacol Exp Ther. 1987;241(1):245-250.

Density	1.24g/cm3
Boiling Point	442.2ºC at 760 mmHg
Molecular Formula	C₁₇H₁₇Cl₂NO
Molecular Weight	322.22900
Flash Point	221.2ºC
Exact Mass	321.06900
PSA	32.59000
LogP	5.33650
Index of Refraction	1.598

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK1253333

CHEMICAL NAME :: Phenol, 2-((butylimino)(2-chlorophenyl)methyl)-4-chloro-

CAS REGISTRY NUMBER :: 80018-06-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H17-Cl2-N-O

MOLECULAR WEIGHT :: 322.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2068960

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