(Pyr6,Pro9)-Substance P (6-11)

Names

[ Name ]:
(Pyr6,Pro9)-Substance P (6-11)

[Synonym ]:
[GLP6,PRO9] SUBSTANCE P (6-11)
PYR-PHE-PHE-PRO-LEU-MET-NH2
SEPTIDE
PYR-FFPLM
[pGlu6,Pro9]substance P-(6-11)
[Glp6,L-Pro9]SP(6-11)
PGLU-PHE-PHE-PRO-LEU-MET-NH2
(PYR6,PRO9)-SUBSTANCE P (6-11)
GLP-PHE-PHE-PRO-LEU-MET-NH2
[pGlu6,Pro9]subustance P(6-11)

Biological Activity

[Description]:

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

Kd: 0.55 ± 0.03 nM (NK1 receptor)[1]

[In Vitro]

Septide increases inositol phosphate levels (4-6-fold) in NK1 receptor expressed CHO cells[2].

[References]

[1]. Hastrup H, Schwartz TW. Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis. FEBS Lett. 1996 Dec 16;399(3):264-6.

[2]. Pradier L, Mayaux JF, et al. Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. Mol Pharmacol. 1994 Feb;45(2):287-93.

Chemical & Physical Properties

[ Density]:
1.255g/cm3

[ Boiling Point ]:
1189.4ºC at 760 mmHg

[ Molecular Formula ]:
C₃₉H₅₀N₁₀O₁₂

[ Molecular Weight ]:
850.87400

[ Flash Point ]:
673.1ºC

[ Exact Mass ]:
850.36100

[ PSA ]:
357.57000

[ Index of Refraction ]:
1.587

(Pyr6,Pro9)-Substance P (6-11)

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds