79775-19-2

79775-19-2 structure

Name: (Pyr6,Pro9)-Substance P (6-11)
Chemical Name: [Pyr6,Pro9]-Substance P (6-11)
CAS Number: 79775-19-2
Molecular Formula: C₃₉H₅₀N₁₀O₁₂
Molecular Weight: 850.87400
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2019-01-29 10:27:23
Modify Date: 2024-01-28 17:38:39
Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM[1].

Name	[Pyr6,Pro9]-Substance P (6-11)
Synonyms	[GLP6,PRO9] SUBSTANCE P (6-11) PYR-PHE-PHE-PRO-LEU-MET-NH2 SEPTIDE PYR-FFPLM [pGlu6,Pro9]substance P-(6-11) [Glp6,L-Pro9]SP(6-11) PGLU-PHE-PHE-PRO-LEU-MET-NH2 (PYR6,PRO9)-SUBSTANCE P (6-11) GLP-PHE-PHE-PRO-LEU-MET-NH2 [pGlu6,Pro9]subustance P(6-11)

Description	Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	Kd: 0.55 ± 0.03 nM (NK1 receptor)[1]
In Vitro	Septide increases inositol phosphate levels (4-6-fold) in NK1 receptor expressed CHO cells[2].
References	[1]. Hastrup H, Schwartz TW. Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis. FEBS Lett. 1996 Dec 16;399(3):264-6. [2]. Pradier L, Mayaux JF, et al. Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. Mol Pharmacol. 1994 Feb;45(2):287-93.