L-AP5

Names

[ Name ]:
L-AP5

[Synonym ]:
D(-)-APV
L-AP5
[3H]-D(-)-2-Amino-5-phosphonopentanoic acid
D-2-Amino-5-phosphonovaleric acid
D-2-Amino-5-phosphopentanoic acid
L-Norvaline, 5-phosphono-
5-Phosphono-D-norvaline
D-Norvaline,5-phosphono
L-(+)-2-Amino-5-phosphonopentanoic acid
Quinolinic acid
D-AP5
D(-)-2-Amino-5-phosphonopentanoic acid

Biological Activity

[Description]:

L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) is an NMDA antagonist and is the isomer of D-AP5 (HY-100714A).L-AP5 shows a relatively weak amino acid and synaptic blocking activity[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

NMDA Receptor

[References]

[1]. Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
482.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₁₂NO₅P

[ Molecular Weight ]:
197.13

[ Flash Point ]:
245.4±31.5 °C

[ Exact Mass ]:
197.045303

[ PSA ]:
130.66000

[ LogP ]:
-2.32

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.536

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36