beta-Estradiol 17-hemisuccinate

Names

[ Name ]:
beta-Estradiol 17-hemisuccinate

[Synonym ]:
17beta-Estradiol hemisuccinate
1,3,5(10)-Estratriene-3,17beta-diol 17-hemisuccinate
4-{[(14beta,17alpha)-3-Hydroxyestra-1,3,5(10)-Trien-17-Yl]oxy}-4-Oxobutanoic Acid
Eutocol (TN)
4-{[(17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl]oxy}-4-oxobutanoic acid
17BETA-ESTRADIOL 17-HEMISUCCINATE
Estradiol-17-hemisuccinate
Butanedioic acid, mono[(17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl] ester
beta-Estradiol 17-hemisuccinate

Biological Activity

[Description]:

β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol (HY-B0141)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Gaikwad NW. Ultra performance liquid chromatography-tandem mass spectrometry method for profiling of steroid metabolome in human tissue. Anal Chem. 2013 May 21;85(10):4951-60.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
570.1±50.0 °C at 760 mmHg

[ Melting Point ]:
162-164°C (lit.)

[ Molecular Formula ]:
C₂₂H₂₈O₅

[ Molecular Weight ]:
372.455

[ Flash Point ]:
198.7±23.6 °C

[ Exact Mass ]:
372.193665

[ PSA ]:
83.83000

[ LogP ]:
4.64

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.598

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332-H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats.

J. Neuroimmunol. , (2008)

Estrogen has been shown to attenuate the inflammatory response following injury or lipopolysaccharide treatment in several organ systems. Estrogen's actions are transduced through two estrogen recepto...

Steroid-bovine serum albumin conjugates: molecular characterization and their interaction with androgen and estrogen receptors.

J. Steroid Biochem. 24(5) , 1017-31, (1986)

Conjugates of testosterone-3-carboxymethyloxime (T-3-CMO), testosterone-17-hemisuccinate (T-17-HS), 17 beta-estradiol-6-carboxymethyloxime (E-6-CMO), or 17 beta-estradiol-17-hemisuccinate (E-17-HS) an...

Prevention of bridge binding in immunoassays: a general estradiol tracer structure.

J. Steroid Biochem. 32(2) , 251-7, (1989)

Iodinated estradiol tracers were synthesized with three different bridges connecting the radiolabelled moiety to the steroid core: Hemisuccinate, carboxymethyloxime and amide. Taking these iodinated t...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.