Diethyl phosphite
Names
[ CAS No. ]:
762-04-9
[ Name ]:
Diethyl phosphite
[Synonym ]:
EINECS 212-091-6
MFCD00044573
Diethyl phosphite
diethoxy(oxo)phosphanium
Chemical & Physical Properties
[ Density]:
1.072 g/mL at 25 °C(lit.)
[ Boiling Point ]:
50-51 °C2 mm Hg(lit.)
[ Melting Point ]:
-70 °C
[ Molecular Formula ]:
C4H11O3P
[ Molecular Weight ]:
138.10200
[ Flash Point ]:
180 °F
[ Exact Mass ]:
138.04500
[ PSA ]:
59.00000
[ LogP ]:
1.44910
[ Index of Refraction ]:
n20/D 1.407(lit.)
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, strong bases. May decompose on exposure to moisture. Combustible.
[ Water Solubility ]:
miscible (hydrolysis)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TG7875000
- CHEMICAL NAME :
- Phosphorous acid, diethyl ester
- CAS REGISTRY NUMBER :
- 762-04-9
- BEILSTEIN REFERENCE NO. :
- 0605759
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C4-H11-O3-P
- MOLECULAR WEIGHT :
- 138.12
- WISWESSER LINE NOTATION :
- 2OPQO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229) Volume(issue)/page/year: #OPB-3,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2020 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82805 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 352 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82805 No. of Facilities: 84 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 505 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38;R43
[ Safety Phrases ]:
S26-S36/37/39-S37/39-S28-S27
[ RIDADR ]:
NA 1993 / PGIII
[ WGK Germany ]:
1
[ RTECS ]:
TG7875000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Am. Chem. Soc. 135(38) , 14082-5, (2013)
We report herein a mild and catalytic phosphonofluorination of unactivated alkenes. With catalysis by AgNO3, the condensation of various unactivated alkenes with diethyl phosphite and Selectfluor reag...
Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system.Org. Lett. 7(22) , 4871-4, (2005)
[reaction: see text] The combination of diethyl phosphite and DMAP as ligands for nickel in an 8:1 THF-N-ethylpyrrolidinone (NEP) mixture allows a very efficient cross-coupling reaction to be performe...
A method for synthesis of homoallylic bromide.J. Org. Chem. 78(12) , 5918-24, (2013)
Cyclopropyl Grignard reagents react with carbonyl compounds in the presence of diethyl phosphite to give homoallylic bromides. The reaction is effectively carried out under mild conditions in a one-po...