Organic Letters 2005-10-27

Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system.

Andrei Gavryushin, Christiane Kofink, Georg Manolikakes, Paul Knochel

Index: Org. Lett. 7(22) , 4871-4, (2005)

Full Text: HTML

Abstract

[reaction: see text] The combination of diethyl phosphite and DMAP as ligands for nickel in an 8:1 THF-N-ethylpyrrolidinone (NEP) mixture allows a very efficient cross-coupling reaction to be performed between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides. The reaction proceeds at 25 degrees C within 1-48 h and requires only 0.05 mol % of the nickel catalyst.

Related Compounds

Related Articles:

Silver-catalyzed radical phosphonofluorination of unactivated alkenes.

2013-09-25

[J. Am. Chem. Soc. 135(38) , 14082-5, (2013)]

A method for synthesis of homoallylic bromide.

2013-06-21

[J. Org. Chem. 78(12) , 5918-24, (2013)]

Synthesis and antiproliferative activity of novel α-aminophosphonates.

2012-01-01

[Chem. Pharm. Bull. 60(12) , 1531-7, (2012)]

Using metal complex ion-molecule reactions in a miniature rectilinear ion trap mass spectrometer to detect chemical warfare agents.

2013-06-01

[J. Am. Soc. Mass Spectrom. 24(6) , 917-25, (2013)]

More Articles...