<Suppliers Price>

NH2-PEG2-C2-Boc

Names

[ CAS No. ]:
756525-95-8

[ Name ]:
NH2-PEG2-C2-Boc

[Synonym ]:
2-Methyl-2-propanyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester
tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
tert-butyl 9-AMino-4,7-dioxanonanoate

Biological Activity

[Description]:

NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

Non-cleavable


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62(2):941-964.

[2]. Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
313.7±22.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H23NO4

[ Molecular Weight ]:
233.305

[ Flash Point ]:
103.3±18.7 °C

[ Exact Mass ]:
233.162704

[ PSA ]:
70.78000

[ LogP ]:
0.48

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.450

Related Compounds