Exo1

Names

[ Name ]:
Exo1

[Synonym ]:
2-(4-Fluorobenzoylamino)benzoic acid methyl ester,2-(4-Fluorobenzoylamino)methylbenzoate
2-(4-FLUOROBENZOYLAMINO)BENZOIC ACID METHYL ESTER
2-(4-Fluoro-benzoylami
4-FLUORO-BZ-2-ABZ-OME
EOX 1
2-(2-METHOXY-BENZYL)-SUCCINIC ACID.
EXO1
EXOCYTIC INHIBITOR 1
2-(4-FLUOROBENZOYLAMINO)METHYLBENZOATE
Exo1,Exocytic Inhibitor 1,2-(4-Fluoro-benzoylaMino)-benzoic acid Methyl ester

Biological Activity

[Description]:

Exo1 is a chemical inhibitor of the exocytic pathway.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[In Vitro]

Exo1 is a modifier of Golgi ARF1 GTPase activity. Because Exo1 affects a subset of the membrane events that are blocked by BFA, but seems to have a different protein target (and presumably has different side effects), it provides an independent means to interfere with Golgi activity. Exo1 Disrupts Vesicular Traffic from the ER to the Golgi apparatus by disrupting Golgi structures. Exo1 inhibits exocytosis with an IC50 of ~20 μM. Exo1 prevents acquisition of endoglycosidase H resistance by newly synthesized proteins such as VSVGts-GFP, transferrin, and MHC class I[1].

[References]

[1]. Feng Y, et al. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6469-74.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.298 g/cm3

[ Boiling Point ]:
333.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₂FNO₃

[ Molecular Weight ]:
273.25900

[ Flash Point ]:
155.8ºC

[ Exact Mass ]:
273.08000

[ PSA ]:
55.40000

[ LogP ]:
2.93760

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport