PRE-084 (hydrochloride)

Names

[ CAS No. ]:
75136-54-8

[ Name ]:
PRE-084 (hydrochloride)

[Synonym ]:
PRE 084 hydrochloride
2-morpholinoacetohydrazide
N-amino-2-morpholin-4-ylacetamide
N-morpholinylacetic acid hydrazide
2-(4-Morpholinyl)ethyl 1-phenylcyclohexanecarboxylate hydrochloride (1:1)
morpholin-4-yl-acetic acid hydrazide
2-(Morpholin-4-yl)ethyl 1-phenylcyclohexanecarboxylate hydrochloride (1:1)
Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1)

Biological Activity

[Description]:

PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.IC50 value: 44 nMTarget: sigma receptorin vitro: PRE-084 has an IC50 of more than 100,000 nM for PCP receptors and an IC50 higher than 10,000 nM in a variety of other receptor systems. [1]in vivo: PRE-084 improves motor neuron survival and motor performance in wobbler mice. PRE-084 enhances BDNF-mediated trophic support.[2]

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Research Areas >> Neurological Disease

[References]

[1]. Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-550.

[2]. Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-232.


[Related Small Molecules]

UNC 0642 | SA 4503 dihydrochloride | BD 1047 dihydrobromide | Noscapine | BD1063 (dhydrochloride) | Siramesine (hydrochloride) | CYR-101 | 4-IBP | AN2/AVex-73 hydrochloride salt | S1RA hydrochloride | Dimemorfan phosphate | Sigma-LIGAND-1

Chemical & Physical Properties

[ Molecular Formula ]:
C19H28ClNO3

[ Molecular Weight ]:
353.884

[ Exact Mass ]:
353.175781

[ PSA ]:
38.77000

[ LogP ]:
3.50380

[ Storage condition ]:
-20℃

Related Compounds