75136-54-8

75136-54-8 structure

Name: PRE-084 (hydrochloride)
Chemical Name: PRE-084 (hydrochloride)
CAS Number: 75136-54-8
Molecular Formula: C₁₉H₂₈ClNO₃
Molecular Weight: 353.884
Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
Create Date: 2016-08-08 12:05:09
Modify Date: 2024-01-03 01:06:20
PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.IC50 value: 44 nMTarget: sigma receptorin vitro: PRE-084 has an IC50 of more than 100,000 nM for PCP receptors and an IC50 higher than 10,000 nM in a variety of other receptor systems. [1]in vivo: PRE-084 improves motor neuron survival and motor performance in wobbler mice. PRE-084 enhances BDNF-mediated trophic support.[2]

Name	PRE-084 (hydrochloride)
Synonyms	PRE 084 hydrochloride 2-morpholinoacetohydrazide N-amino-2-morpholin-4-ylacetamide N-morpholinylacetic acid hydrazide 2-(4-Morpholinyl)ethyl 1-phenylcyclohexanecarboxylate hydrochloride (1:1) morpholin-4-yl-acetic acid hydrazide 2-(Morpholin-4-yl)ethyl 1-phenylcyclohexanecarboxylate hydrochloride (1:1) Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1)

Description	PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.IC50 value: 44 nMTarget: sigma receptorin vitro: PRE-084 has an IC50 of more than 100,000 nM for PCP receptors and an IC50 higher than 10,000 nM in a variety of other receptor systems. [1]in vivo: PRE-084 improves motor neuron survival and motor performance in wobbler mice. PRE-084 enhances BDNF-mediated trophic support.[2]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Research Areas >> Neurological Disease
References	[1]. Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-550. [2]. Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-232.