CIMOXATONE

Names

[ Name ]:
CIMOXATONE

[Synonym ]:
Cimoxatone
Cimoxatone (INN)
Cimoxatonum [INN-Latin]
EINECS 277-613-7
Cimoxatono [INN-Spanish]

Biological Activity

[Description]:

Cimoxatone (MD 780515) is a reversible, selectively and orally active type A monoamine oxidase (MAO-A) inhibitor. Cimoxatone enhances the anorectic action of Serotonin (HY-B1473A)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Metabolic Disease

[Target]

MAO-A

[In Vivo]

Cimoxatone (20 mg/kg; p.o.) 增强 5-HT (1 mg/kg; s.c.) 对大鼠的厌食作用[1]。 Animal Model: 250-300 g, Adult male Wistar rats[1] Dosage: 20 mg/kg Administration: P.o. Result: Significiantly reduced sucrose intake induced by 1 mg/kg 5-HT or its vehicle injected 2 and 24 h later, significantly enhanced the anorectic action of 5-HT at 2 h but not at 24 h.

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
509.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₈N₂O₄

[ Molecular Weight ]:
338.35700

[ Flash Point ]:
261.8ºC

[ Exact Mass ]:
338.12700

[ PSA ]:
71.79000

[ LogP ]:
3.17388

[ Index of Refraction ]:
1.613

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI4710000

CHEMICAL NAME :: Benzonitrile, 3-((4-(5-(methoxymethyl)-2-oxo-3-oxazolidinyl)phenoxy )methyl)-

CAS REGISTRY NUMBER :: 73815-11-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H18-N2-O4

MOLECULAR WEIGHT :: 338.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982