L-Isoleucine

Names

[ CAS No. ]:
73-32-5

[ Name ]:
L-Isoleucine

[Synonym ]:
Ile
QVYZY2&1 &&(2S,3S)- or L(+)- Form
H-ILE-OH
L-Ile
N-methyl Ile
MFCD00064222
UNII:5HX0BYT4E3
H-DL-Ile-OH
a-Amino-b-methylvaleric Acid
L-Ile (2S,3S)
L-Isoleucine
EINECS 200-798-2
2-Amino-3-methylvaleric acid
DL-2-Amino-3-methylpentanoic acid
L-Isoleucine (JP15)
2-amino-3-methylpentanoic acid
(2S,3S)-a-Amino-b-methyl-n-valeric acid
H-lle-OH
Isoleucin
(2S,3S)-a-Amino-b-methylvaleric acid
Isoleucine
(2S,3S)-2-amino-3-methylpentanoic acid
(2S,3S)-2-Amino-3-methylpentanoicacid
Z-(s,S)-isoleucine
L-Isoleusine
Isoleucine, DL-
H-L-ILE-OH
ISOLEUCINE, L-
ISO-LEUCINE
(S,S)-Isoleucine
(±)-Isoleucine
DL-Isoleucine
Acetic acid, amino-sec-butyl-
(2S,3S)-Ile
Isoleucine, L- (8CI)
(±)-erythro-2-Amino-3-methylpentanoic acid
(S)-isoleucin
L-Isoieucine
(2S,3S)-2-amino-3-methyl-Pentanoic acid
L(+)-Isoleucin

Biological Activity

[Description]:

L-Isoleucine is one of 20 proteinogenic amino acids. L-Isoleucine is an essential amino acid.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Others

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
225.8±23.0 °C at 760 mmHg

[ Melting Point ]:
168-170ºC

[ Molecular Formula ]:
C₆H₁₃NO₂

[ Molecular Weight ]:
131.173

[ Flash Point ]:
90.3±22.6 °C

[ Exact Mass ]:
131.094635

[ PSA ]:
63.32000

[ LogP ]:
0.73

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.463

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR4705000

CHEMICAL NAME :: Isoleucine, L-

CAS REGISTRY NUMBER :: 73-32-5

LAST UPDATED :: 199707

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H13-N-O2

MOLECULAR WEIGHT :: 131.20

WISWESSER LINE NOTATION :: QVYZY2&1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6822 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4368 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - changes in sodium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81864 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81864 No. of Facilities: 740 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 18202 (estimated) No. of Female Employees: 13865 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NR4705000

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

A substrate ambiguous enzyme facilitates genome reduction in an intracellular symbiont.

BMC Biol. 12 , 110, (2015)

Genome evolution in intracellular microbial symbionts is characterized by gene loss, generating some of the smallest and most gene-poor genomes known. As a result of gene loss these genomes commonly c...

Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.

J. Agric. Food Chem. 63 , 5670-81, (2015)

In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effec...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...