chlorquinaldol

Names

[ CAS No. ]:
72-80-0

[ Name ]:
chlorquinaldol

[Synonym ]:
5,7-Dichloro-2-methyl-8-quinolinol
5,7-Dichloro-8-hydroxyquinaldine
2-methyl-5,7-dichloro-8-hydroxyquinoline
5,7-Dichloro-8-quinaldinol
Clorquinaldol
Chloroquinaldol
EINECS 200-789-3
Gynotherax
5,7-dichloro-2-methylquinolin-8-ol
2-methylchloroxine
5,7-Dichlor-2-methylchinolin-8-ol
Saprosan
Sterosan
5,7-dichloro-2-methyl-8-hydroxy-quinoline
8-Quinolinol, 5,7-dichloro-2-methyl-
chlorquinaldol
Chlorchinaldolum
Chlorquinaldolum
MFCD00023984

Biological Activity

[Description]:

Chlorquinaldol is a mono-hydroxyquinoline, is an antifungal and antibacterial, used for topical treatment of skin conditions and vaginal infections.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
350.7±37.0 °C at 760 mmHg

[ Melting Point ]:
108-112 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₇Cl₂NO

[ Molecular Weight ]:
228.075

[ Flash Point ]:
165.9±26.5 °C

[ Exact Mass ]:
226.990463

[ PSA ]:
33.12000

[ LogP ]:
4.21

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.679

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC5600000

CHEMICAL NAME :: 8-Quinolinol, 5,7-dichloro-2-methyl-

CAS REGISTRY NUMBER :: 72-80-0

BEILSTEIN REFERENCE NO. :: 0156683

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H7-Cl2-N-O

MOLECULAR WEIGHT :: 228.08

WISWESSER LINE NOTATION :: T66 BNJ C1 GG IG JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Mold - Aspergillus nidulans

DOSE/DURATION :: 1 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
VC5600000

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Purity determination of gynalgin bactericidal tablets with HPLC method.

Acta Pol. Pharm. 70(1) , 51-8, (2013)

The study was aimed at developing a simple HPLC method for the determination of the content of impurities in Gynalgin, a two-component preparation. A satisfactory separation was performed on 250 x 4.6...

[Allergies to 8-hydroxyquinoline derivatives].

Derm. Beruf Umwelt. 36(3) , 86-90, (1988)

Evaluation of our standardized test results from 1972 to 1983 indicated Vioform allergies in 1.2% of all cases and Sterosan allergies in 1.1%. Our results are within the spectrum found in the literatu...

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

Antimicrob. Agents Chemother. 51 , 1105-6, (2007)

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/...