2-Phenyl-6,7-dimethylquinoxaline

Names

[ Name ]:
2-Phenyl-6,7-dimethylquinoxaline

[Synonym ]:
AG 1295
2-Phenyl-6,7-dimethylquinoxaline
F1284-0835
TYRPHOSTIN AG 1295
6,7-Dimethyl-2-phenylquinoxaline
6,7-dimethyl-2-phenyl-quinoxaline
Quinoxaline, 6,7-dimethyl-2-phenyl-
6,7-Dimethyl-2-phenyl-chinoxalin

Biological Activity

[Description]:

AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG 1295 reduces neointimal formation in aortic allograft vasculopathy by inhibition of PDGFR-beta-triggered tyrosine phosphorylation[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR

[Target]

PDGFR[1]

[References]

[1]. Zheng Y, et al. Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy. Jpn J Ophthalmol. 2003 Mar-Apr;47(2):158-65.

[2]. Inhibition of aortic allograft vasculopathy by local delivery of platelet-derived growth factor receptor tyrosine-kinase blocker AG-1295. Transplantation. 2002 Nov 15;74(9):1335-41.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
398.3±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂

[ Molecular Weight ]:
234.296

[ Flash Point ]:
172.4±17.8 °C

[ Exact Mass ]:
234.115692

[ PSA ]:
25.78000

[ LogP ]:
3.92

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22;S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%