Glycolophenone

Names

[ CAS No. ]:
582-24-1

[ Name ]:
Glycolophenone

[Synonym ]:
2-Hydroxyacetophenone
MFCD00041829
Glycolophenone
EINECS 209-480-8
Methanol, benzoyl-
Benzoylcarbinol
2-Hydroxy-1-phenylethanone
HYDROXYACETOPHENONE
α-hydroxyacetophenone
Ethanone, 2-hydroxy-1-phenyl-

Biological Activity

[Description]:

2-Hydroxyacetophenone is a principal root volatile of the Carissa edulis[1]. 2-Hydroxyacetophenone shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 1.8 mM[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

HIV

[References]

[1]. M D Bentley, et al. 2-Hydroxyacetophenone: principal root volatile of the East African medicinal plant, Carissa edulis. J Nat Prod. Nov-Dec 1984;47(6):1056-7.

[2]. Min Zhuang, et al. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Res. 2009 Apr;82(1):73-81.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
244.6±13.0 °C at 760 mmHg

[ Melting Point ]:
86-89 °C(lit.)

[ Molecular Formula ]:
C₈H₈O₂

[ Molecular Weight ]:
136.148

[ Flash Point ]:
100.4±12.4 °C

[ Exact Mass ]:
136.052429

[ PSA ]:
37.30000

[ LogP ]:
0.44

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.551

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Urinalysis of minor metabolites of ethylbenzene and m-xylene.

Scand. J. Work. Environ. Health 10(2) , 75-81, (1984)

Gas chromatographic methods have been developed for the urinalysis of metabolic products of ethylbenzene. "Minor" metabolites were emphasized in this process. The methods were worked out so that simul...

Synthesis and structural characterization of mixed ligand ? 1-2-hydroxyacetophenone complexes of cobalt (III). Mondal N, et al.

Polyhedron 19(28) , 2707-11, (2000)

Solvent-free microwave-assisted Beckmann rearrangement of benzaldehyde and 2-hydroxyacetophenone oximes. Loupy A and Régnier S.

Tetrahedron Lett. 40(34) , 6221-24, (1999)