3'-Deoxycytidine

Names

[ Name ]:
3'-Deoxycytidine

[Synonym ]:
4-Amino-1-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone
4-Amino-1-(3-deoxy-β-D-erythro-pentofuranosyl)pyrimidin-2(1H)-on
3'-deoxy-cytidine
3'-Deoxycytidine
3'-deoxyribicytidine
3'-Deoxy-D-cytidine
3'-deoxycytidine free base
Cytidine, 3'-deoxy-

Biological Activity

[Description]:

4-Amino-1-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (3'-Deoxycytidine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
497.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₃N₃O₄

[ Molecular Weight ]:
227.22

[ Flash Point ]:
254.8±31.5 °C

[ Exact Mass ]:
227.090607

[ PSA ]:
110.60000

[ LogP ]:
-1.70

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.720

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA3830000

CHEMICAL NAME :: Cytidine, 3'-deoxy-

CAS REGISTRY NUMBER :: 7057-33-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H13-N3-O4

MOLECULAR WEIGHT :: 227.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Fibroblast

DOSE/DURATION :: 1 mg/L

REFERENCE :: CBRPDS Cell Biology International Reports. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 2,279,1978