N-Boc-L-Prolinol
Names
[ CAS No. ]:
69610-40-8
[ Name ]:
N-Boc-L-Prolinol
[Synonym ]:
tert-butyl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
tert-butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
(S)-(-)-1-Boc-2-pyrrolidinemethanol
MFCD00066232
N-Boc-L-prolinol
2-Methyl-2-propanyl (2S)-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
Boc-Pro-Ol
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
289.5±13.0 °C at 760 mmHg
[ Melting Point ]:
60-64ºC
[ Molecular Formula ]:
C10H19NO3
[ Molecular Weight ]:
201.26
[ Flash Point ]:
128.9±19.8 °C
[ Exact Mass ]:
201.136490
[ PSA ]:
49.77000
[ LogP ]:
0.46
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.484
[ Storage condition ]:
2~8°C
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. 12 , 2099-2114, (2004)
Since factor Xa (fXa) plays a pivotal role in the blood coagulation cascade, inhibition of fXa is thought to be an effective treatment for a variety of thrombotic events. (2S)-2-[4-[[(3S)-1-Acetimidoy...
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.J. Med. Chem. 39 , 817-825, (1996)
Recent evidence indicating the therapeutic potential of cholinergic channel modulators for the treatment of central nervous system (CNS) disorders as well as the diversity of brain neuronal nicotine a...
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.J. Med. Chem. 40 , 385, (1997)
2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine, ABT-089 (S-4), a member of the 3-pyridyl ether class of nicotinic acetylcholine receptor (nAChR) ligands, shows positive effects in rodent and primate mo...