2'-Hydroxy-4'-methylacetophenone

Names

[ Name ]:
2'-Hydroxy-4'-methylacetophenone

[Synonym ]:
EINECS 230-040-6
1-(2-hydroxy-4-methylphenyl)ethanone
MFCD00100559
2'-Hydroxy-4'-methylacetophenone

Biological Activity

[Description]:

2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots possesses acaricidal property[1]. It could be used in the preparation of 4’-methyl-2’-[(p-tolylsulfonyl) oxy] acetophenone[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Phenols

[References]

[1]. Oh MS, et al. Acaricidal toxicity of 2'-hydroxy-4'-methylacetophenone isolated from Angelicae koreana roots and structure-activity relationships of its derivatives. J Agric Food Chem. 2012 Apr 11;60(14):3606-11.

[2]. De Meyer N, et al. 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. J Med Chem. 1991 Feb;34(2):736-46.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.08 g/mL at 25 °C(lit.)

[ Boiling Point ]:
245 °C(lit.)

[ Melting Point ]:
45-48ºC

[ Molecular Formula ]:
C₉H₁₀O₂

[ Molecular Weight ]:
150.17400

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
150.06800

[ PSA ]:
37.30000

[ LogP ]:
1.90320

[ Index of Refraction ]:
n20/D 1.565(lit.)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Acaricidal toxicity of 2'-hydroxy-4'-methylacetophenone isolated from Angelicae koreana roots and structure-activity relationships of its derivatives.

J. Agric. Food Chem. 60(14) , 3606-11, (2012)

The acaricidal activities of 2'-hydroxy-4'-methylacetophenone derived from Angelica koreana roots and its derivatives against Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus p...

Zirconium tetrachloride as a mediator for ambient temperature ortho-fries rearrangements. Harrowven DC and Dainty RF.

Tetrahedron 37(42) , 7659-7660, (1996)

4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. De Meyer N, et al.

J. Med. Chem. 34(2) , 736-746, (1991)

Related Compounds

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